Endocrine Abstracts

Selenium (Se) is indispensable for enzymatic activities of glutathione peroxidases (GPx) involved in antioxidative defense and deiodinase isozymes (Dio) that control thyroid hormone (TH) action. Se deficiency can impact negatively on thyroid galnd funtioning and TH metabolism and thereby perturb development and metabolism. We have generated Se-deficient mice by genetic inactivation of Selenoprotein P (SePP), the main plasma Se carrier. SePP-KO mice display decreased serum and ...

The aim of our study was to evaluate the reference ranges of thyrotropin (TSH) and free thyroxin (FT4) assayed with 5 methods at the second and the third trimesters of pregnancy for women with iodine intake at the lower limit of the normal range. This study used 297 sera (42 controls without pregnancy with age <40 years, 139 women at the second trimester and 116 at the third with mean age to 27 years in both groups). The assays were for TSH (Elecsys Roche), for thyroproxid...